ISSN 1302-6631
 

Case Report 


Psychosis in Kallmann Syndrome: a case illustration based on possible genetic liability

Simge Seren Kırlıoğlu, Yasin Hasan Balcıoğlu, Pınar Çetinay Aydın.

Abstract
Kallmann Syndrome (KS) is an uncommon disorder caused by a deficient production or secretion of gonadotropin-releasing hormone (GnRH) and manifests with an absence of spontaneous puberty and impaired sense of smell. Multiple inheritance patterns have been recognized in the etiology. KS and psychosis have occasionally been con-sidered to originate in similar predisposing genetic profile. Defective KAL-X gene which had previously been attributed in the etiopathogenesis of schizophrenia was asserted to lead to an impairment in the migration of GnRH neurons and olfactory deficits in various severity and disruption in sexual developmental, consequently. Our case is a 19-year-old male previously diagnosed with KS at his 13, who has been under the monthly intramuscular treat-ment of testosterone propionate and testosterone phenylpropionate at the dose of 250 mg. He was admitted to our clinic with auditory and visual hallucinations that started two years ago. Persecutory delusions, social isolation, and suicidal thoughts also existed. We diagnosed him schizophrenia with comorbid KS following the hospitalization and a detailed psychiatric examination. Olanzapine was initiated as 5 mg/day and potentiated to 15 mg/day. His delu-sions, hallucinations and suicidal thoughts had improved with the treatment. In this illustration, we purposed to discuss probable common etiopathogenesis underlying this comorbidity.

Key words: Growth factors, Kallmann Syndrome, schizophrenia



Kallmann Sendromu’nda psikoz: olası genetik yatkınlık zemininde bir olgu bildirimi

Ozet
Kallmann Sendromu (KS), gonadotropin salgılatıcı hormon (GnRH) üretimindeki veya salgılanmasındaki eksikliğe bağlı ortaya çıkan ve spontan pubertenin yokluğu ile koku duyusunda bozulmanın izlendiği sık görülmeyen bir hastalıktır. Etiyolojisinde çoklu genetik örüntüler yer almaktadır. KS ve psikozun ortak yatkınlaştırıcı genetik profil-den köken aldığına zaman zaman dikkat çekilmiştir. Şizofreninin etiyopatogenezinde rol oynadığı öne sürülen bozuk KAL-X geninin GnRH nöronlarının migrasyonda bozulmaya ve sonuç olarak değişen şiddette olfaktör kusuruna ve normal cinsel gelişim sürecinde bozulmaya yol açtığı gösterilmiştir. Olgumuza 13 yaşındayken KS tanısı konmuş, halen aylık 250 mg testosteron propiyonat ve testosteron fenilpropiyonat intramuskuler uygulanan 19 yaşında bir erkektir. Hasta, kliniğimize iki yıl önce başlayan işitsel ve görsel varsanılar yakınmasıyla başvurmuştur. Hastamızda aynı zamanda kötülük görme sanrıları, sosyal izolasyon ve intihar düşünceleri de vardı. Ayrıntılı psikiyatrik muayene ve kliniğe yatışını izleyerek şizofreni tanısı konan hastanın tedavisine olanzapin 5 mg/gün ile başlanmış ve aşamalı olarak artırılarak 15 mg/güne yükseltilmiştir. Varsanıları, sanrıları ve intihar düşünceleri tedaviyle iyileşme göster-miştir. Bu yazıda söz konusu eş tanının altında yatan olası ortak etiyopatogenezin tartışılması amaçlanmıştır.

Anahtar Kelimeler: Büyüme faktörleri, Kallmann Sendromu, şizofreni


 
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Pubmed Style

Kirlioglu SS, Balcioglu YH, Aydin PC. Psychosis in Kallmann Syndrome: a case illustration based on possible genetic liability. Anadolu Psikiyatri Derg. 2018; 19(4): 427-430. doi:10.5455/apd.295629


Web Style

Kirlioglu SS, Balcioglu YH, Aydin PC. Psychosis in Kallmann Syndrome: a case illustration based on possible genetic liability. http://www.anadolupsikiyatri.net/?mno=295629 [Access: July 20, 2018]. doi:10.5455/apd.295629


AMA (American Medical Association) Style

Kirlioglu SS, Balcioglu YH, Aydin PC. Psychosis in Kallmann Syndrome: a case illustration based on possible genetic liability. Anadolu Psikiyatri Derg. 2018; 19(4): 427-430. doi:10.5455/apd.295629



Vancouver/ICMJE Style

Kirlioglu SS, Balcioglu YH, Aydin PC. Psychosis in Kallmann Syndrome: a case illustration based on possible genetic liability. Anadolu Psikiyatri Derg. (2018), [cited July 20, 2018]; 19(4): 427-430. doi:10.5455/apd.295629



Harvard Style

Kirlioglu, S. S., Balcioglu, Y. H. & Aydin, P. C. (2018) Psychosis in Kallmann Syndrome: a case illustration based on possible genetic liability. Anadolu Psikiyatri Derg, 19 (4), 427-430. doi:10.5455/apd.295629



Turabian Style

Kirlioglu, Simge Seren, Yasin Hasan Balcioglu, and Pinar Cetinay Aydin. 2018. Psychosis in Kallmann Syndrome: a case illustration based on possible genetic liability. Anatolian Journal of Psychiatry, 19 (4), 427-430. doi:10.5455/apd.295629



Chicago Style

Kirlioglu, Simge Seren, Yasin Hasan Balcioglu, and Pinar Cetinay Aydin. "Psychosis in Kallmann Syndrome: a case illustration based on possible genetic liability." Anatolian Journal of Psychiatry 19 (2018), 427-430. doi:10.5455/apd.295629



MLA (The Modern Language Association) Style

Kirlioglu, Simge Seren, Yasin Hasan Balcioglu, and Pinar Cetinay Aydin. "Psychosis in Kallmann Syndrome: a case illustration based on possible genetic liability." Anatolian Journal of Psychiatry 19.4 (2018), 427-430. Print. doi:10.5455/apd.295629



APA (American Psychological Association) Style

Kirlioglu, S. S., Balcioglu, Y. H. & Aydin, P. C. (2018) Psychosis in Kallmann Syndrome: a case illustration based on possible genetic liability. Anatolian Journal of Psychiatry, 19 (4), 427-430. doi:10.5455/apd.295629





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