SERUM COPPER, ZINC AND SELENIUM LEVELS IN RHEUMATOID ARTHRITIS

Mesut Çolak; Namık Kemal Bingöl; Oğuz Ayhan; Şenel Avcı; Vedat Bulut

Original Article

Vol. 16 No. 2 (2001): The Archives of Rheumatology

PDF

Published: Jun 30, 2001

Keywords:

Rheumatoid arthritis, selenium, zinc, copper

How to Cite

Mesut Çolak, Namık Kemal Bingöl, Oğuz Ayhan, Şenel Avcı, & Vedat Bulut. (2001). SERUM COPPER, ZINC AND SELENIUM LEVELS IN RHEUMATOID ARTHRITIS. Archives of Rheumatology, 16(2), 066–071. Retrieved from http://anadolupsikiyatri.net/index.php/pub/article/view/44

Mesut Çolak

Internal Medicine Department, Fırat Medical Centre, Medical School, Firat University

Namık Kemal Bingöl

Biochemistry Department, Gulhane Military Medical Academy

Oğuz Ayhan

Internal Medicine Department, Fırat Medical Centre, Medical School, Firat University

Şenel Avcı

Clinical Biochemistry Department, Medical School, Harran University

Vedat Bulut

Immunology Department, Firat Medical Centre, Medical School, Firat University

Mesut Çolak

Internal Medicine Department, Fırat Medical Centre, Medical School, Firat University

Namık Kemal Bingöl

Biochemistry Department, Gulhane Military Medical Academy

Oğuz Ayhan

Internal Medicine Department, Fırat Medical Centre, Medical School, Firat University

Şenel Avcı

Clinical Biochemistry Department, Medical School, Harran University

Vedat Bulut

Immunology Department, Firat Medical Centre, Medical School, Firat University

Abstract

The objective of this study was to measure the alterations in some important serum trace elements, including selenium (Se), zinc (Zn), copper (Cu), in patients with rheumatoid arthritis (RA). In the study, serum trace elements were determined by using Atomic Absorption Spectrophotometer in sera of patients with RA (n=32), and statistically compared with healthy individuals (n=52). Serum Cu concentration was found significantly higher in patients group than those of healthy individuals (26,06±4,.71 and 17,74±3,30 µmol/L, respectively) (p<0,001). In contrary, Se and Zn levels were lower in patients (0,18±0,05 µmol/L and 6,58±3,14 µmol/L, respectively) according to the healthy subjects (0,21±0,06 µmol/L and 11.44±6,00 µmol/L, respectively).

Our results showed that serum trace elements (Se, Zn and Cu) concentrations are altered in RA patients. The changes may be a part of autoimmune process in organism induced by cytokines. In conclusion, we suggest that decrease in Zn and Se levels and elevation in Cu levels are probably responsive to inflammation and resulted from defence strategies of organism and mediated by the hormone-like substances.