Examining Sirtuin-1 Levels and Inflammation Markers in Behcet's Disease: A Pilot Study
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Abstract
Background/Aims: Assess circulatory Sirtuin-1 (SIRT1) levels in Behcet's disease (BD) and relationships with disease activity and inflammatory markers.
Materials and Methods: Forty BD patients and 40 matched controls. Recorded demographics, disease activity (BDCAF), treatments, organ involvement. Measured CRP, IL-6, TNF-α, and SIRT1 in fasting blood.
Results: CRP, IL-6, TNF-α higher in BD vs controls, regardless of activity. SIRT1 similar across groups and treatments. Patients with vascular + ocular involvement had lower SIRT1 than ocular only.
Conclusion: Circulatory SIRT1 levels are similar in BD and controls but may associate with vascular involvement.
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