ISSN 1302-6631
 

Case Report 


Schizophrenia and mega cisterna magna: case report

Semra Karayılan, Atila Erol.

Abstract
Mega cisterna magna (MCM) is a developmental malformation of the posterior fossa, morphologically vermis and cerebellar hemispheres are intact. Although the relationship between this anomaly and psychiatric disorders is emphasized, its nature has not fully understood. In this article, we report a case of schizophrenia detected mega cisterna magna. A 35-year-old, married, housewife, graduated from primary school, female patient was brought to our clinic by her relatives with complaints of disorganized and inappropriate speech, strange behavior. She had auditory and visual hallucinations, delusions of reference and persecution. Neurological examination and EEG examination were normal, but mega cisterna magna was disclosed in her cranial magnetic resonance imaging scan. The relationship between psychosis and clinical significance of MCM has not defined completely yet. The role of the cerebellum in schizophrenia has been highlighted by Andreasen’s hypothesis of ‘cognitive dysmetria’. This hypothesis suggests that cerebellum has a role in general dyscoordination of sensorimotor and mental processes which are seen in schizophrenic patients. Schizophrenic patients are known to have problems about memory and verbal fluency, too. In the context of this case, the relationship of schizophrenia with cerebellar anomalies was reviewed.
Key words:

Key words: schizophrenia, mega cisterna magna, cerebellum, brain imaging methods



Şizofreni ve mega sisterna magna: Olgu sunumu

Ozet
Mega sisterna magna, posterior fossanın gelişimsel bir malformasyonudur ve morfolojik olarak vermis ve sere-bellar hemisferler etkilenmemiştir. Bu anomalinin psikiyatrik bozukluklarla ilişkisi vurgulanmış olmakla birlikte, doğası tam olarak anlaşılamamıştır. Mega sisterna magna saptanan bir şizofreni olgusu sunuyoruz. Otuz beş yaşında, kadın, evli, ev kadını, ilkokul mezunu hasta yakınları tarafından dağınık ve uygunsuz konuşma, tuhaf davranma belirtileri ile kliniğimize getirildi. İşitsel ve görsel varsanılar, alınma ve kötülük görme sanrıları vardı. Nörolojik muayenesi ve EEG incelemesi normaldi, fakat kraniyal manyetik rezonans görüntülemesinde mega sisterna magna saptandı. Mega sisterna magnanın psikozla ilişkisi ve klinik önemi tam olarak tanımlanmamıştır. Andreasen’in ‘bilişsel dismetri’ varsayımında serebellumun şizofrenideki rolü vurgulanmıştır. Bu varsayım, şizofre-ni hastalarında görülen sensorimotor ve zihinsel süreçlerin genel bir eşgüdüm bozukluğunda serebellumun rolü olduğunu öne sürmektedir. Şizofreni hastalarında da hareket ve sözel akıcılıkla ilgili sorunlar olduğu bilinmektedir. Bu olgu bağlamında serebellar anomaliler ile şizofreni ilişkisi gözden geçirilmiştir.

Anahtar Kelimeler: Şizofreni, mega sisterna magna, serebellum, beyin görüntüleme yöntemleri


 
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REFERENCES
1. Levitt JJ, McCarley RW, Nestor PG, Petrescu C, Donnino R, Hirayasu Y, et al. Quantitative volumetric MRI study of the cerebellum and vermis in schizophrenia: clinical and cognitive correlates. Am J Psychiatry 1999; 156:1105-1107.
2. Schmahmann JD. From movement to thought: anatomic substrates of the cerebellar contribution to cognitive processing. Hum Brain Mapp 1996; 4:174-198. [DOI via Crossref]   
3. Leiner HC, Leiner AL, Dow RS. The underestimated cerebellum. Hum Brain Mapp 1995; 2:244-254. [DOI via Crossref]   
4. Picard H, Amado I, Mages SM, Olie JP, Krebs MO. The role of the cerebellum in schizophrenia: an update of clinical, cognitive, and functional evidences. Schizophr Bull 2008; 34:55-172.
5. Zimmer EZ, Lowenstein L, Bronshtein M, Goldsher D, Peretz JA. Clinical significance of isolated mega cisterna magna. Arch Gynecol Obstet 2007; 276:487-490. [DOI via Crossref]    [Pubmed]   
6. Turan T, Beþirli A, Asdemir A, Özsoy S, Eþel E. Manic episode associated with mega cisterna magna. Psychiatry Investig 2010; 7:305-307. [DOI via Crossref]    [Pubmed]    [PMC Free Fulltext]   
7. Langarica M, Peralta V. [Psychosis associated to megacisterna magna.] An Sist Sanit Navar 2005; 28:119-121.
8. Turner R, Schiavetto A. The Cerebellum in schizophrenia: a case of intermittent ataxia and psychosis-clinical, cognitive, and neuroanatomical correlates. J Neuropsychiatry Clin Neurosci 2004; 16:4.
9. Andreasen NC, O’Leary DS, Cizadlo T, Arndt S, Rezai K, Boles Ponto LL, et al. Schizophrenia and cognitive dysmetria: A positron-emission tomography study of dysfunctional prefrontalthalamic-cerebellar circuitry. Proc Natl Acad Sci USA 1996; 93:9985-9990. [DOI via Crossref]   
10. Andreasen NC. A unitary model of schizophrenia:Bleuler’s ‘fragmented phrene’ as schizencephaly. Arch Gen Psychiatry 1999; 56:781-787. [DOI via Crossref]    [Pubmed]   

How to Cite this Article
Pubmed Style

Semra Karayilan, Atila Erol. [Schizophrenia and mega cisterna magna: case report]. Anadolu Psikiyatri Derg. 2013; 14(1): 90-92. Turkish. doi:10.5455/apd.36699


Web Style

Semra Karayilan, Atila Erol. [Schizophrenia and mega cisterna magna: case report]. http://www.anadolupsikiyatri.net/?mno=36699 [Access: April 01, 2020]. Turkish. doi:10.5455/apd.36699


AMA (American Medical Association) Style

Semra Karayilan, Atila Erol. [Schizophrenia and mega cisterna magna: case report]. Anadolu Psikiyatri Derg. 2013; 14(1): 90-92. Turkish. doi:10.5455/apd.36699



Vancouver/ICMJE Style

Semra Karayilan, Atila Erol. [Schizophrenia and mega cisterna magna: case report]. Anadolu Psikiyatri Derg. (2013), [cited April 01, 2020]; 14(1): 90-92. Turkish. doi:10.5455/apd.36699



Harvard Style

Semra Karayilan, Atila Erol (2013) [Schizophrenia and mega cisterna magna: case report]. Anadolu Psikiyatri Derg, 14 (1), 90-92. Turkish. doi:10.5455/apd.36699



Turabian Style

Semra Karayilan, Atila Erol. 2013. [Schizophrenia and mega cisterna magna: case report]. Anatolian Journal of Psychiatry, 14 (1), 90-92. Turkish. doi:10.5455/apd.36699



Chicago Style

Semra Karayilan, Atila Erol. "[Schizophrenia and mega cisterna magna: case report]." Anatolian Journal of Psychiatry 14 (2013), 90-92. Turkish. doi:10.5455/apd.36699



MLA (The Modern Language Association) Style

Semra Karayilan, Atila Erol. "[Schizophrenia and mega cisterna magna: case report]." Anatolian Journal of Psychiatry 14.1 (2013), 90-92. Print.Turkish. doi:10.5455/apd.36699



APA (American Psychological Association) Style

Semra Karayilan, Atila Erol (2013) [Schizophrenia and mega cisterna magna: case report]. Anatolian Journal of Psychiatry, 14 (1), 90-92. Turkish. doi:10.5455/apd.36699