ISSN 1302-6631
 

Original Research (Original Article) 


The effect of brain derived neurotrophic factor Val66Met polymorphism upon alcohol dependence tendency in Turkish alcohol dependents

Burçin Tezcanlı Kaymaz, Ayşe Ender Altıntoprak, Bülent Kayahan, Çağdaş Aktan, Hakan Coşkunol, Buket Kosova.

Abstract
Objective: The neurotrophine “brain derived neurotrophic factor” (BDNF) which is expressed in the brain is responsible for neuronal survive and functioning also plays a role in pathophysiology of alcohol dependence that show multifactorial and polygenic heredity. In the current study, we aimed to identify whether the functional Val66Met [G196A; (rs6265)] polymorphism in BDNF gene has effect upon tendency to alcoholism in Turkish male and female alcohol dependent cases. Methods: Genotype distribution and allele frequency of BDNF Val66Met polymorphism was identified via PCR-RFLP (Polymerase Chain Reaction-Restriction Fragment Length Polymorphism) method in 110 alcoholic cases (10 female, 100 male) and 376 healthy subjects (148 female, 228 male) constituting our study and control groups, statistical analyses were revealed by chi-square and ANOVA tests. Results: The distribution of the mutant AA genotype was 3.6% to 1.6% and frequency of the A allele was 16.0% to 15.0% in the study group when compared to control group. Our results didn’t show any significant differences in genotype distribution and allele frequencies of polymorphism neither between the study and control groups nor between female case and female controls and male alcoholics and male controls. The power of the study for genotype analysis was set at 80.2%. Conclusion: These results indicate that the polymorphic A allele of BDNF gene is not related with alcoholism in Turkish subjects. But since AA genotyped male subjects’ starting ages of alcohol usage and pathological drinking were detected to be earlier among other genotypes, this gave rise to a conclusion that BDNF polymorphism might be important in the alcoholism phenotype.

Key words: alcohol dependence, brain derived neurotrophic factor, BDNF Val66Met, polymorphism



Türk alkol bağımlılarında beyin kaynaklı nörotrofik faktör Val66Met polimorfizminin alkol bağımlılığına yatkınlık üzerine etkisi

Özet
Amaç: Multifaktöriyel ve poligenik kalıtım gösteren alkol bağımlılığının patofizyolojisinde, beyinde ifade edilen ve nöronal yaşam ile işlevsellikten sorumlu bir nörotrofin olan “beyin kaynaklı nörotrofik faktör” (BDNF) geni de rol almaktadır. Çalışmamızda, BDNF genindeki işlevsel Val66Met [G196A; (rs6265)] polimorfizminin Türk kadın ve erkek alkol bağımlısı olgularının alkol bağımlılığı yatkınlığı üzerine etkisinin olup olmadığının belirlenmesi amaçlanmıştır. Yöntem: Çalışma ve kontrol gruplarını oluşturan 110 alkol bağımlısı olgu (10 kadın, 100 erkek) ve 376 sağlıklı bireyde (148 kadın, 228 erkek) BDNF Val66Met polimorfizminin genotip dağılımı ve alel sıklığı PZR-RFLP (Polimeraz Zincir Reaksiyonu-Restriksiyon Fragment Uzunluk Polimorfizmi) yöntemiyle belirlenmiş, istatistiksel analizler ki-kare ve ANOVA testleriyle gerçekleştirilmiştir. Bulgular: Çalışma grubunu oluşturan olgular, kontrol grubu olgularıyla karşılaştırıldığında; mutant AA genotipinin dağılımı %3.6’ya karşı %1.6 iken, A alelinin sıklığı %16.0’a karşı %15.0 olarak belirlenmiştir. Bulgularımıza göre, çalışma grubu ve kontrol grubu, kadın olgular ile kadın kontroller ve erkek olgular ile erkek kontroller arasında genotip dağılımı ve alel sıklığı açısından anlamlı bir fark bulunmamaktadır. Çalışmanın gücü genotip analizi açısından %80.2 olarak hesaplanmıştır. Sonuç: Bu bulgular, BDNF geni polimorfik A alelinin Türk olgularda alkol bağımlılığıyla ilişkisinin olmadığını göstermektedir. Ancak AA genotipli erkek olguların alkol kullanmaya ve sorunlu içiciliğe başlama yaşının diğer genotiplere göre daha erken olduğunun belirlenmesi, alkol bağımlılığı fenotipinde BDNF polimorfizminin önemli olabileceğini düşündürmektedir.

Anahtar Kelimeler: Alkol bağımlılığı, beyin kaynaklı nörotrofik faktör, BDNF Val66Met, polimorfizm


 
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How to Cite this Article
Pubmed Style

Kaymaz BT, Altintoprak AE, Kayahan B, Aktan C, Coskunol H, Kosova B. [The effect of brain derived neurotrophic factor Val66Met polymorphism upon alcohol dependence tendency in Turkish alcohol dependents]. Anadolu Psikiyatri Derg. 2013; 14(1): 1-9. Turkish. doi:10.5455/apd.34461


Web Style

Kaymaz BT, Altintoprak AE, Kayahan B, Aktan C, Coskunol H, Kosova B. [The effect of brain derived neurotrophic factor Val66Met polymorphism upon alcohol dependence tendency in Turkish alcohol dependents]. http://www.anadolupsikiyatri.net/?mno=34461 [Access: June 23, 2018]. Turkish. doi:10.5455/apd.34461


AMA (American Medical Association) Style

Kaymaz BT, Altintoprak AE, Kayahan B, Aktan C, Coskunol H, Kosova B. [The effect of brain derived neurotrophic factor Val66Met polymorphism upon alcohol dependence tendency in Turkish alcohol dependents]. Anadolu Psikiyatri Derg. 2013; 14(1): 1-9. Turkish. doi:10.5455/apd.34461



Vancouver/ICMJE Style

Kaymaz BT, Altintoprak AE, Kayahan B, Aktan C, Coskunol H, Kosova B. [The effect of brain derived neurotrophic factor Val66Met polymorphism upon alcohol dependence tendency in Turkish alcohol dependents]. Anadolu Psikiyatri Derg. (2013), [cited June 23, 2018]; 14(1): 1-9. Turkish. doi:10.5455/apd.34461



Harvard Style

Kaymaz, B. T., Altintoprak, A. E., Kayahan, B., Aktan, C., Coskunol, H. & Kosova, B. (2013) [The effect of brain derived neurotrophic factor Val66Met polymorphism upon alcohol dependence tendency in Turkish alcohol dependents]. Anadolu Psikiyatri Derg, 14 (1), 1-9. Turkish. doi:10.5455/apd.34461



Turabian Style

Kaymaz, Burcin Tezcanli, Ayse Ender Altintoprak, Bulent Kayahan, Cagdas Aktan, Hakan Coskunol, and Buket Kosova. 2013. [The effect of brain derived neurotrophic factor Val66Met polymorphism upon alcohol dependence tendency in Turkish alcohol dependents]. Anatolian Journal of Psychiatry, 14 (1), 1-9. Turkish. doi:10.5455/apd.34461



Chicago Style

Kaymaz, Burcin Tezcanli, Ayse Ender Altintoprak, Bulent Kayahan, Cagdas Aktan, Hakan Coskunol, and Buket Kosova. "[The effect of brain derived neurotrophic factor Val66Met polymorphism upon alcohol dependence tendency in Turkish alcohol dependents]." Anatolian Journal of Psychiatry 14 (2013), 1-9. Turkish. doi:10.5455/apd.34461



MLA (The Modern Language Association) Style

Kaymaz, Burcin Tezcanli, Ayse Ender Altintoprak, Bulent Kayahan, Cagdas Aktan, Hakan Coskunol, and Buket Kosova. "[The effect of brain derived neurotrophic factor Val66Met polymorphism upon alcohol dependence tendency in Turkish alcohol dependents]." Anatolian Journal of Psychiatry 14.1 (2013), 1-9. Print.Turkish. doi:10.5455/apd.34461



APA (American Psychological Association) Style

Kaymaz, B. T., Altintoprak, A. E., Kayahan, B., Aktan, C., Coskunol, H. & Kosova, B. (2013) [The effect of brain derived neurotrophic factor Val66Met polymorphism upon alcohol dependence tendency in Turkish alcohol dependents]. Anatolian Journal of Psychiatry, 14 (1), 1-9. Turkish. doi:10.5455/apd.34461





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