ISSN 1302-6631
 

Original Research (Original Article) 


Evaluation of sleep quality of early buprenorphine/naloxone treatment in opioid addicted patients

Hüseyin Şipka, Erdal Vardar.

Abstract
Objective: Opioid addiction is a chronic, relapsing and psychosocial disorder. In opioid addiction patients, studies show that sleep disorders, deteriorated quality of sleep and sleep architecture changes might be seen. In addition, comorbid psychiatric disorder and depression are frequently seen in opioid addicts. Comorbid psychiatric disorders and symptoms worsen of sleep quality in opioid addicts. This study aims to evaluate the quality of sleep during the periods of pre-treatment and in early opioid agonist maintenance treatment in the opioid addicts. Methods: The research included 29 patients in the Alcohol and Substance Addiction Treatment Unit of Trakya University Faculty of Medicine who have met diagnostic criteria for opioid addiction according to DSM-5, completed 28-day treatment, and admitted for control to Alcohol and Substance Addiction Treatment Unit after 1 month from discharge. The Hamilton Depression Rating Scale, Hamilton Anxiety Rating Scale, Pittsburgh Sleep Quality Index are administered to all the patients who participated to the study on the day 1, day 28, and in the month 2. All the patients were treated with buprenorphine and naloxone combination. Results: In our study, a time-dependent significant de-crease from day 1 to month 2 was determined in the average scores of the Pittsburgh Sleep Quality Index, which evaluates the sleep quality. In addition, the Pittsburgh Sleep Quality Index average scores showed differences in all time periods. Our study also determined a time-dependent significant decrease in the average scores of the Hamilton Depression Rating Scale and the Hamilton Anxiety Rating Scale, which evaluates respectively the depressive symptoms and anxiety symptoms on the day 0, day 28 and day 60. Discussion: In our research, we evaluated the sleep quality and the symptoms of depression and anxiety of the patients diagnosed with opioid addiction in pre-treatment and early period of opioid agonist maintenance treatment, and showed that those symptoms were getting better with treatment. We think that these findings can guide further research, as they show that opioid treat-ment does not only serve for addiction treatment but also for the treatment of the symptoms accompanying the opioid addiction.

Key words: Opioid addiction, sleep, depression, anxiety, buprenorphine, naloxone



Buprenorfin/nalokson tedavisi gören opiyat bağımlısı hastalarda tedavinin erken döneminde uyku kalitesinin değerlendirilmesi

Ozet
Amaç: Opiyat bağımlılığı kronik, yineleyici ve biyopsikososyal bir bozukluktur. Opiyat bağımlılarında uyku bozukluk-ları, uyku kalitesinde bozulma ve uyku yapısında farklılıklar görülebilmektedir. Buna ek olarak opiyat bağımlılarında depresyon ve diğer psikiyatrik bozukluk eş tanısı sık görülmektedir. Psikiyatrik belirtiler ve eş tanı bu hastalarda uyku kalitesini bozmaktadır. Bu çalışmada opiyat bağımlılığı olan hastalarda tedavi öncesi, opiyattan arındırma ve opiyat parsiyel agonist idame tedavisi süresince uyku kalitelerinin değerlendirilmesi amaçlanmıştır. Yöntem: Araş-tırmaya DSM-5 ölçütlerine göre opiyat kullanım bozukluğu tanı ölçütlerini karşılayan, 28 günlük tedavi programını tamamlayan ve taburculuk sonrası birinci ayda AMATEM polikliniğine izleme kontrolüne gelen 29 hasta alınmıştır. Araştırma katılan tüm hastalara 1. gün, 28. gün ve 2. ayda Hamilton Depresyon Derecelendirme Ölçeği, Hamilton Anksiyete Değerlendirme Ölçeği, Pittsburgh Uyku Kalitesi Ölçeği uygulanmıştır. Hastaların hepsi buprenorfin/nalok-son kombinasyonu ile tedavi edilmişlerdir. Sonuçlar: Araştırmamızda 1. gün, 28. gün ve 2. ayda uyku kalitelerinin anlamlı olarak düzeldiği ve uykusuzluğun azaldığı; ayrıca 1. gün, 28. gün ve 2. ayda depresif ve anksiyete belirtile-rinde zamana göre anlamlı bir düşüş olduğu bulunmuştur. Tartışma: Araştırmamızda opiyat bağımlılığı hastala-rında uyku kalitesi, depresif ve anksiyete belirtilerinin tedavi öncesi ve opiyat parsiyel agonist tedavisinin erken dönemi süresince düzelme gösterdiği saptanmıştır. Bu bulgular opiyat bağımlılarında bağımlılık ile beraber, uyku-suzluk gibi eşlik eden ruhsal belirtilerin de tedavi ile düzeldiğini göstermiştir.

Anahtar Kelimeler: Opiyat bağımlılığı, uyku, depresyon, anksiyete, buprenorfin, nalokson


 
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Pubmed Style

Sipka H, Vardar E. [Evaluation of sleep quality of early buprenorphine/naloxone treatment in opioid addicted patients]. Anadolu Psikiyatri Derg. 2018; 19(5): 466-471. Turkish. doi:10.5455/apd.294903


Web Style

Sipka H, Vardar E. [Evaluation of sleep quality of early buprenorphine/naloxone treatment in opioid addicted patients]. http://www.anadolupsikiyatri.net/?mno=294903 [Access: July 20, 2018]. Turkish. doi:10.5455/apd.294903


AMA (American Medical Association) Style

Sipka H, Vardar E. [Evaluation of sleep quality of early buprenorphine/naloxone treatment in opioid addicted patients]. Anadolu Psikiyatri Derg. 2018; 19(5): 466-471. Turkish. doi:10.5455/apd.294903



Vancouver/ICMJE Style

Sipka H, Vardar E. [Evaluation of sleep quality of early buprenorphine/naloxone treatment in opioid addicted patients]. Anadolu Psikiyatri Derg. (2018), [cited July 20, 2018]; 19(5): 466-471. Turkish. doi:10.5455/apd.294903



Harvard Style

Sipka, H. & Vardar, E. (2018) [Evaluation of sleep quality of early buprenorphine/naloxone treatment in opioid addicted patients]. Anadolu Psikiyatri Derg, 19 (5), 466-471. Turkish. doi:10.5455/apd.294903



Turabian Style

Sipka, Huseyin, and Erdal Vardar. 2018. [Evaluation of sleep quality of early buprenorphine/naloxone treatment in opioid addicted patients]. Anatolian Journal of Psychiatry, 19 (5), 466-471. Turkish. doi:10.5455/apd.294903



Chicago Style

Sipka, Huseyin, and Erdal Vardar. "[Evaluation of sleep quality of early buprenorphine/naloxone treatment in opioid addicted patients]." Anatolian Journal of Psychiatry 19 (2018), 466-471. Turkish. doi:10.5455/apd.294903



MLA (The Modern Language Association) Style

Sipka, Huseyin, and Erdal Vardar. "[Evaluation of sleep quality of early buprenorphine/naloxone treatment in opioid addicted patients]." Anatolian Journal of Psychiatry 19.5 (2018), 466-471. Print.Turkish. doi:10.5455/apd.294903



APA (American Psychological Association) Style

Sipka, H. & Vardar, E. (2018) [Evaluation of sleep quality of early buprenorphine/naloxone treatment in opioid addicted patients]. Anatolian Journal of Psychiatry, 19 (5), 466-471. Turkish. doi:10.5455/apd.294903





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