ISSN 1302-6631
 

Original Research (Original Article) 


May BPA and phthalates have a role in etiopathogenesis of ADHD?

Didem Behice Öztop, Esra Demirci, Sevgi Özmen, Meda Kondolot, Fatih Kardaş, hüseyin per.

Abstract
Objective: Although the etiology ofattention deficit hyperactivity disorder (ADHD) is unknown, it is thought that endocrine disruptors may be involved in the etiopathogenesis. The aim of this study was to investigate the relation-ship between ADHD development and exposure to mono-(2-ethylhexyl) phthalate (MEHP), di-(2-ethylhexyl) phtha-late (DEHP), and bisphenol A (BPA). Methods: The study included 44 children who were diagnosed with ADHD according to DSM IV-TR diagnostic criteria and 51 healthy children as controls. In all subjects, serum MEHP, DEHP, and BPA were measured by using high performance liquid chromatography (HPLC). Results: Serum MEHP and BPA levels were found to be significantly higher in the ADHD group (0.47±0.22 µg/ml, 1.48±0.28 ng/ml) than the controls (0.31±0.13 µg/ml, 0.91±0.23 ng/ml). There was no difference in the level of DEHP between the ADHD group and healthy controls (2.17±0.69 µg/ml, 2.26±0.56 µg/ml). Conclusion: Our results could be accepted as an evidence to support an association between BPA, MEHPlevels and ADHD. However, further studies are needed to clarify the linkage between ADHD and endocrine disruptors.

Key words: ADHD, children, bisphenol A, phthalates, etiology.



DEHB etyopatogenezinde BPA ve Fitalatların rolü olabilir mi?

Ozet
Amaç: Dikkat eksikliği hiperaktivite bozukluğunun (DEHB) etiyolojisi tam olarak bilinmemekle birlikte, etiyopato-genezinde endokrin bozucuların rol oynadığı düşünülmektedir. Bu çalışmanın amacı, ADHD gelişimi ile mono- (2-etilheksil) fitalat (MEHP), di- (2-etilheksil) fitalat (DEHP) ve bisfenol A'ya (BPA) maruz kalma arasındaki ilişkiyi araştırmaktır. Yöntem: Çalışmaya, DSM-IV-TR tanı ölçütlerine göre DEHB tanısı konan 44 çocuk ve kontrol grubu olarak 51 sağlıklı çocuk alındı. Tüm olgularda, serum MEHP, DEHP ve BPA, yüksek performanslı sıvı kromatografisi (HPLC) kullanılarak ölçüldü. Bulgular: Serum MEHP ve BPA düzeyleri DEHB grubunda (0.474±0.223 µg/ml, 1.485±0.285 ng/ml) kontrole (0.311±0.134 µg/ml, 906±0.232 ng/ml) göre istatistiksel olarak anlamlı yüksek bulundu. DEHP düzeyleri açısından her iki grup karşılaştırıldığında aralarında anlamlı fark bulunmadı (2.168±0.694 µg/ml, 2.262±0.565 µg/ml). Sonuç: Çalışmamızın sonuçları MEHP ve BPA düzeyleri ile DEHB arasındaki ilişki olduğunu destekler nitelikte kabul edilebilir. Bununla birlikte, DEHB ve endokrin bozucular arasındaki bağlantıyı açıklığa kavuşturmak için daha ileri çalışmalara gerek vardır.

Anahtar Kelimeler: DEHB, çocuk, bisfenol A, fitalat, etyoloji.


 
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How to Cite this Article
Pubmed Style

Oztop DB, Demirci E, Ozmen S, Kondolot M, Kardas F, per h. May BPA and phthalates have a role in etiopathogenesis of ADHD?. Anadolu Psikiyatri Derg. 2018; 19(3): 300-306. doi:10.5455/apd.280093


Web Style

Oztop DB, Demirci E, Ozmen S, Kondolot M, Kardas F, per h. May BPA and phthalates have a role in etiopathogenesis of ADHD?. http://www.anadolupsikiyatri.net/?mno=280093 [Access: July 20, 2018]. doi:10.5455/apd.280093


AMA (American Medical Association) Style

Oztop DB, Demirci E, Ozmen S, Kondolot M, Kardas F, per h. May BPA and phthalates have a role in etiopathogenesis of ADHD?. Anadolu Psikiyatri Derg. 2018; 19(3): 300-306. doi:10.5455/apd.280093



Vancouver/ICMJE Style

Oztop DB, Demirci E, Ozmen S, Kondolot M, Kardas F, per h. May BPA and phthalates have a role in etiopathogenesis of ADHD?. Anadolu Psikiyatri Derg. (2018), [cited July 20, 2018]; 19(3): 300-306. doi:10.5455/apd.280093



Harvard Style

Oztop, D. B., Demirci, E., Ozmen, S., Kondolot, M., Kardas, F. & per, h. (2018) May BPA and phthalates have a role in etiopathogenesis of ADHD?. Anadolu Psikiyatri Derg, 19 (3), 300-306. doi:10.5455/apd.280093



Turabian Style

Oztop, Didem Behice, Esra Demirci, Sevgi Ozmen, Meda Kondolot, Fatih Kardas, and huseyin per. 2018. May BPA and phthalates have a role in etiopathogenesis of ADHD?. Anatolian Journal of Psychiatry, 19 (3), 300-306. doi:10.5455/apd.280093



Chicago Style

Oztop, Didem Behice, Esra Demirci, Sevgi Ozmen, Meda Kondolot, Fatih Kardas, and huseyin per. "May BPA and phthalates have a role in etiopathogenesis of ADHD?." Anatolian Journal of Psychiatry 19 (2018), 300-306. doi:10.5455/apd.280093



MLA (The Modern Language Association) Style

Oztop, Didem Behice, Esra Demirci, Sevgi Ozmen, Meda Kondolot, Fatih Kardas, and huseyin per. "May BPA and phthalates have a role in etiopathogenesis of ADHD?." Anatolian Journal of Psychiatry 19.3 (2018), 300-306. Print. doi:10.5455/apd.280093



APA (American Psychological Association) Style

Oztop, D. B., Demirci, E., Ozmen, S., Kondolot, M., Kardas, F. & per, h. (2018) May BPA and phthalates have a role in etiopathogenesis of ADHD?. Anatolian Journal of Psychiatry, 19 (3), 300-306. doi:10.5455/apd.280093





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