ISSN 1302-6631
 

Original Research (Original Article) 


Thyroid gland functions are affected in obsessive-compulsive disorder

Osman Mermi, Murad Atmaca.

Cited by (1)

Abstract
Objective: In the present study, it was aimed to examine thyroid functions in a group of patients with OCD who had not any comorbid conditions. Methods: Our present study included forty patients diagnosed with OCD and forty healthy controls. The subjects were selected by the chart reviews among the patients with OCD who had applied to the Firat University School of Medicine Department of Psychiatry, as inpatients or outpatients and had met the criteria of the present investigation. Thyroid hormone values had been obtained by using an auto analyzer. Results: Independent t test revealed that there were no statistically significant differences thyroid stimulating hormone (TSH) values between the patients with OCD and healthy control subjects whereas there were statistically significant reduced levels of free triiodothyronine (FT3) and free thyroxine (FT4) hormones in the patient group compared to those of healthy ones. Conclusion: Consequently, altered levels of thyroid hormones may be associated with pathophysiology or maintenance of OCD.

Key words: OCD, TSH, thyroid hormones



Obsesif kompulsif bozuklukta tiroit işlevleri etkilenmektedir

Ozet
Amaç: Çalışmamızda, komorbid durumu olmayan obsesif kompulsif bozukluklu (OKB) bir grup hastada tiroit işlevlerinin incelenmesi amaçlanmıştır. Yöntem: Çalışmaya 40 OKB hastası ve 40 sağlıklı kontrol grubu alındı. Denekler, Fırat Üniversitesi Tıp Fakültesi Psikiyatri Bölümü’nde ayaktan veya yatarak tedavi gören ve çalışma ölçütlerini karşılayan OKB hastalarının dosyalarının geriye dönük taranmasıyla seçildi. Tiroit hormon değerleri oto-analizer kullanılarak elde edildi. Bulgular: Bağımsız t testi, tiroit salgılatıcı hormon (TSH) düzeylerinin OKB grubu ile sağlıklı kontrol grubu arasında istatistiksel olarak anlamlı fark olmadığını, serbest triiyodotironin (sT3) ve serbest tiroksin (sT4) düzeylerinin ise hasta grubunda, kontrol grubuna göre istatistiksel olarak anlamlı düzeyde azaldığını ortaya koymuştur. Sonuç: Sonuç olarak, tiroit hormonlarının düzeylerindeki değişiklik, OKB’nin patofizyolojisiyle veya hastalığın kliniğinin sürmesiyle ilişkili olabilir.

Anahtar Kelimeler: OKB, TSH, tiroid hormonları


 
ARTICLE TOOLS
Abstract
PDF Fulltext
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by Osman Mermi
Articles by Murad Atmaca
on Google
on Google Scholar
Article Statistics
 Viewed: 4546
Downloaded: 2719
Cited: 1


REFERENCES
1. Ozaki N, Goldman D, Kaye WH, Polotnicov K, Greenberg BD, Lappalainen J, et al. Serotonin transporter missense mutation associated with a complex neuropsychiatric phenotype. Mol Psychiatry 2003; 8:933-936. [DOI via Crossref]    [Pubmed]   
2. Kuloglu M, Atmaca M, Tezcan E, Gecici O, Tunckol H, Ustundag B. Antioxidant enzyme activities and malondialdehyde levels in patients with obsessive-compulsive disorder. Neuropsychobiology 2002; 46:27-32. [DOI via Crossref]    [Pubmed]   
3. Atmaca M, Yildirim H, Ozdemir H, Tezcan E, Poyraz AK. Volumetric MRI study of key brain regions implicated in obsessive-compulsive disorder. Prog Neuropsychopharmacol Biol Psychiatry 2007; 31:46-52. [DOI via Crossref]    [Pubmed]   
4. Atmaca M, Yildirim H, Ozdemir H, Aydýn A, Tezcan E, Ozler S. Volumetric MRI assessment of brain regions in patients with refractory obsessivecompulsive disorder. Prog Neuropsychopharmacol Biol Psychiatry 2006; 30:1051-1057. [DOI via Crossref]    [Pubmed]   
5. Wittthauer C, Gloster AT, Meyer AH, Lieb R. Physical diseases among person with obsessive symptoms and disorder: a general population study. Soc Psychiatr Epidemiol 2014; 49:2013-2022. [DOI via Crossref]    [Pubmed]    [PMC Free Fulltext]   
6. Aizenberg D, Hermesh H, Gil-ad I, Munitz H, Tyano S, Laron Z, et al. TRH stimulation test in obsessive-compulsive patients. Psychiatry Res 1991; 38:21-26. [DOI via Crossref]   
7. Joffe RT, Swinson RP. Thyroid function in obsesssive-compulsive disorder. Psychiatric Journal of the University of Ottawa 1988; 13:215-216. [Pubmed]   
8. Hantouche E, Piketty ML, Poirier MF, Brochier T, Olié JP. Obsessive-compulsive disorder and the study of thyroid function. Encephale (Article in French) 1991; 17:493-496. [Pubmed]   
9. Bhatara V, Alshari MG, Warho P, McMillin JM, Bhatara A. Coexistent hypothyroidism, psychosis, and severe obsessions in an adolescent: a 10-year follow-up. J Child Adolesc Psychopharmacol 2004; 14:315-323. [DOI via Crossref]    [Pubmed]   
10. McCracken JT, Hanna GL. Elevated thyroid indices in children and adolescents with obsessivecompulsive disorder: effects of clomipramine treatment. J Child Adolesc Psychopharmacol 2005; 15:581-587. [DOI via Crossref]    [Pubmed]   
11. Patten SB, Williams BA, Esposito E, Beck CA. Self-reported thyroid disease and mental disorder prevelance in the general population. Gen Hosp Psychiatry 2006; 28:503-508. [DOI via Crossref]    [Pubmed]   
12. Bauer M, Heinz A, Whybrow PC. Thyroid hormones, serotonin and mood: of synergy and significance in the adult brain. Mol Psychiatry 2002; 7:140-156. [DOI via Crossref]    [Pubmed]   

This Article Cited By the following articles

From Protein Variations to Biological Processes and Pathways with NET-GE
Genomics Comput Biol 2017; 3(3): 45.

1
 
How to Cite this Article
Pubmed Style

Osman Mermi, Murad Atmaca. Thyroid gland functions are affected in obsessive-compulsive disorder. Anadolu Psikiyatri Derg. 2016; 17(2): 99-103. doi:10.5455/apd.178087


Web Style

Osman Mermi, Murad Atmaca. Thyroid gland functions are affected in obsessive-compulsive disorder. http://www.anadolupsikiyatri.net/?mno=178087 [Access: April 01, 2020]. doi:10.5455/apd.178087


AMA (American Medical Association) Style

Osman Mermi, Murad Atmaca. Thyroid gland functions are affected in obsessive-compulsive disorder. Anadolu Psikiyatri Derg. 2016; 17(2): 99-103. doi:10.5455/apd.178087



Vancouver/ICMJE Style

Osman Mermi, Murad Atmaca. Thyroid gland functions are affected in obsessive-compulsive disorder. Anadolu Psikiyatri Derg. (2016), [cited April 01, 2020]; 17(2): 99-103. doi:10.5455/apd.178087



Harvard Style

Osman Mermi, Murad Atmaca (2016) Thyroid gland functions are affected in obsessive-compulsive disorder. Anadolu Psikiyatri Derg, 17 (2), 99-103. doi:10.5455/apd.178087



Turabian Style

Osman Mermi, Murad Atmaca. 2016. Thyroid gland functions are affected in obsessive-compulsive disorder. Anatolian Journal of Psychiatry, 17 (2), 99-103. doi:10.5455/apd.178087



Chicago Style

Osman Mermi, Murad Atmaca. "Thyroid gland functions are affected in obsessive-compulsive disorder." Anatolian Journal of Psychiatry 17 (2016), 99-103. doi:10.5455/apd.178087



MLA (The Modern Language Association) Style

Osman Mermi, Murad Atmaca. "Thyroid gland functions are affected in obsessive-compulsive disorder." Anatolian Journal of Psychiatry 17.2 (2016), 99-103. Print. doi:10.5455/apd.178087



APA (American Psychological Association) Style

Osman Mermi, Murad Atmaca (2016) Thyroid gland functions are affected in obsessive-compulsive disorder. Anatolian Journal of Psychiatry, 17 (2), 99-103. doi:10.5455/apd.178087